Translational selection in human: more pronounced in housekeeping genes
نویسندگان
چکیده
منابع مشابه
Mammalian housekeeping genes evolve more slowly than tissue-specific genes.
Do housekeeping genes, which are turned on most of the time in almost every tissue, evolve more slowly than genes that are turned on only at specific developmental times or tissues? Recent large-scale gene expression studies enable us to have a better definition of housekeeping genes and to address the above question in detail. In this study, we examined 1581 human-mouse orthologous gene pairs ...
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For accurate and reliable gene expression analysis, normalization of gene expression data against housekeeping genes (reference or internal control genes) is required. It is known that commonly used housekeeping genes (e.g. ACTB, GAPDH, HPRT1, and B2M) vary considerably under different experimental conditions and therefore their use for normalization is limited. We performed a meta-analysis of ...
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Genome Biol. 2, 1018 13 Gray, M.W. et al. (1999) Mitochondrial evolution. Science 283, 1476–1481 14 Lang, B.F. et al. (1999) A comparative genomics approach to the evolution of eukaryotes and their mitochondria. J. Eukaryot. Microbiol. 46, 320–326 15 Henze, K. and Martin, W. (2001) How do mitochondrial genes get into the nucleus? Trends Genet. 17, 383–387 16 Chinnery, P.F. (2003) Searching for ...
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The stability of housekeeping genes (HKGs) is critical when performing real-time quantitative PCR. To date, the stability of common HKGs has not been systematically compared in human airway epithelial cells (AEC) in normal and atopic subjects. Expression levels of 12 HKGs were measured in AECs from a cohort of 30 healthy atopic nonasthmatic or atopic asthmatic children. Gene expression stabilit...
متن کاملOn the nature of human housekeeping genes.
Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. We found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. Housekeeping genes ...
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ژورنال
عنوان ژورنال: Biology Direct
سال: 2014
ISSN: 1745-6150
DOI: 10.1186/1745-6150-9-17